Holt T M, Hawkins R K
Res Commun Chem Pathol Pharmacol. 1978 May;20(2):239-51.
In this study, 13 groups of rats were injected with the insecticide Disulfoton (0-0-diethyl S-2-[(ethylthio) ethyl] phosphorodithioate), sacrificed after various time intervals and levels of hippocampal norepinephrine determined. Results indicate that this cholinesterase inhibiting compound caused a significant decrease (congruent to 14%) in hippocampal norepinephrine within 3 hours of exposure. This reduction was maintained for at least 48 hours. Titers of norepinephrine had returned to control levels when measured 5 days after a single drug administration. Chronic poisoning also caused depressed norepinephrine levels, although not significantly below those observed in acutely treated animals.
在本研究中，给13组大鼠注射了杀虫剂乙拌磷（0-0-二乙基-S-2-[(乙硫基)乙基]二硫代磷酸酯），在不同时间间隔后将大鼠处死，并测定海马去甲肾上腺素水平。结果表明，这种胆碱酯酶抑制化合物在接触后3小时内可使海马去甲肾上腺素显著降低（约14%）。这种降低至少维持48小时。单次给药5天后测量时，去甲肾上腺素滴度已恢复至对照水平。慢性中毒也会导致去甲肾上腺素水平降低，尽管未显著低于急性处理动物所观察到的水平。
