Adams F, Quesada J R, Gutterman J U
JAMA. 1984 Aug 17;252(7):938-41.
The conditions of ten patients with metastatic renal cell carcinoma were serially evaluated by neuropsychiatric examination to determine the nature of the fatigue-asthenia symptoms resulting from human leukocyte interferon alpha therapy. The majority of the patients had moderate to severe behavioral changes and mild to moderate cognitive, affective, and personality changes within the first week of daily intramuscular administration of 3 X 10(6) units of interferon. This descriptive clinical study suggests that the intense fatigue may be a manifestation of a complex neurotoxicity, most suggestive of frontal lobe changes, and resulting in neurasthenia syndrome with reversible impairment of some higher mental functions.
通过神经精神检查对10例转移性肾细胞癌患者的病情进行了连续评估，以确定人类白细胞α干扰素治疗所致疲劳-乏力症状的性质。在每天肌肉注射3×10⁶单位干扰素的第一周内，大多数患者出现了中度至重度行为改变以及轻度至中度认知、情感和人格改变。这项描述性临床研究表明，强烈的疲劳可能是一种复杂神经毒性的表现，最提示额叶改变，并导致神经衰弱综合征，伴有某些高级心理功能的可逆性损害。
