MacKichan J J, Pyszczynski D R, Jusko W J
Res Commun Chem Pathol Pharmacol. 1978 Jun;20(3):531-8.
A sensitive and specific fluorometric high pressure liquid chromatography technique was used to measure propranolol concentrations in the plasma of three healthy volunteers following an oral 10 mg dose of propranolol hydrochloride. Peak propranolol concentrations were 6 to 8 ng/ml and half-lives ranged fro 2.5 to 5.6 hours. The threshold concept for hepatic uptake or oral propranolol is less marked than previously reported.
采用一种灵敏且特异的荧光高压液相色谱技术，对三名健康志愿者口服10毫克盐酸普萘洛尔后血浆中的普萘洛尔浓度进行测定。普萘洛尔的峰值浓度为6至8纳克/毫升，半衰期为2.5至5.6小时。肝脏摄取或口服普萘洛尔的阈值概念不如先前报道的那么明显。
