Schimmelpfennig B
Klin Monbl Augenheilkd. 1984 May;184(5):353-6. doi: 10.1055/s-2008-1054488.
Age-related changes in corneal endothelial cell size were investigated in 116 eyes, from newborn to 96 years of age, by light microscopy. The preliminary findings show a regional distribution of cell changes on the endothelial surface. The endothelium of a newborn was homogeneous in cell size and shape. From the third decade of life onward, polymorphism and cell size variations occurred in the central endothelium. In corneas of patients over 50 years old, one-third of the cases often had a geographic arrangement of cells of increased size in the mid-periphery (3.5-4.0 mm paracentrally). Small cells were always predominant at the periphery.
通过光学显微镜对116只年龄从新生儿到96岁的眼睛进行了角膜内皮细胞大小与年龄相关变化的研究。初步研究结果显示，内皮表面细胞变化存在区域分布差异。新生儿的内皮细胞在大小和形状上较为均匀。从生命的第三个十年开始，中央内皮细胞出现多态性和细胞大小变化。在50岁以上患者的角膜中，三分之一的病例在中周边部（距角膜中心3.5 - 4.0毫米处）常常出现细胞大小增加的地图状排列。周边部始终以小细胞为主。
