Bustamante B, Crabbé J
J Steroid Biochem. 1984 Jun;20(6A):133-6.
Cortisol concentration was measured by radioimmunoassay in parotid saliva: values for normal subjects averaged 15 nM at 8:00 and 4 nM at 18:00. Parotid saliva cortisol was shown to react promptly and in a clearcut fashion to factors leading to rise and fall in cortisol secretion. Cortisol levels in parotid saliva were uninfluenced in young women taken estrogen-containing drugs for contraceptive purposes; on the other hand, they increased significantly during the third trimester of pregnancy. This increase corresponds to the reported increase in ultrafilterable cortisol, itself being presumably the result of the hypersection of progesterone characterizing this physiological condition since progesterone competes with cortisol not only at the level of transcortin but also at that of cytoplasmic glucocorticoid receptors.
正常受试者在8:00时的平均值为15 nM，18:00时为4 nM。腮腺唾液中的皮质醇对导致皮质醇分泌增减的因素反应迅速且明确。服用含雌激素避孕药的年轻女性，其腮腺唾液中的皮质醇水平不受影响；另一方面，在妊娠晚期皮质醇水平显著升高。这种升高与报道的可超滤皮质醇的增加相一致，这可能是由于该生理状态下孕酮分泌过多所致，因为孕酮不仅在皮质素水平，而且在细胞质糖皮质激素受体水平与皮质醇竞争。
