DNA中匹配序列的频率。

The frequency of matching sequences in DNA.

作者信息

Moore G P, Moore A R, Grossman L I

出版信息

J Theor Biol. 1984 May 7;108(1):111-22. doi: 10.1016/s0022-5193(84)80172-1.

Abstract

Equations are presented which allow prediction of the number of direct or indirect matching sequences in DNA. Predicted match frequencies can be calculated for any match length, DNA strand length and DNA base composition, assuming only that the DNA sequence is random. The effect of varying these parameters is described, and match frequency is related to the total frequency of repeats. Equations were verified by computer search of randomly generated DNA sequences. A group of published DNA sequences was searched for matches and the results compared to the calculated predictions for random DNA. In general, natural DNA was found to be similar to random DNA with respect to frequency of matching sequences.

摘要

文中给出了一些方程式，这些方程式可用于预测DNA中直接或间接匹配序列的数量。假设DNA序列是随机的，那么对于任何匹配长度、DNA链长度和DNA碱基组成，都可以计算出预测的匹配频率。文中描述了改变这些参数的影响，并且匹配频率与重复序列的总频率相关。通过对随机生成的DNA序列进行计算机搜索，验证了这些方程式。对一组已发表的DNA序列进行匹配搜索，并将结果与随机DNA的计算预测结果进行比较。一般来说，就匹配序列的频率而言，天然DNA与随机DNA相似。