The antagonistic action of 6-aminomethyl-3-methyl-4H,1,2, 4-benzothiadiazine-1,1-dioxide (TAG) on the prolactin-releasing action of taurine.

The action of the putative taurine antagonist 6-aminomethyl-3-methyl-4H-1, 2,4-benzothiadiazine-1,1 dioxide (TAG) was examined on the prolactin-releasing action of taurine. The study utilized unanesthetized male rats with indwelling jugular and cerebroventricular cannulas. The intracerebroventricular (I.C.V.) infusion of taurine (0.5 mumole) elicited an increase in prolactin (PRL) secretion elevating plasma levels significantly by 10 min. The I.C.V. infusion of TAG (0.01 mumole) did not alter baseline plasma PRL levels. When a combined I.C.V. infusion of taurine and TAG was given the PRL levels normally induced by taurine were significantly reduced. Neither taurine nor the antagonist TAG altered pituitary secretion of luteinizing hormone.