Rosen E M, Cassady J R, Kretschmar C, Frantz C N, Levey R, Sallan S E
Med Pediatr Oncol. 1984;12(4):260-3. doi: 10.1002/mpo.2950120410.
Data relative to the prognostic and therapeutic significance of lymph node metastases in regionally confined neuroblastoma (Evans stages II-III) are scant. We have analyzed lymph node status in order to assess the significance of nodal involvement. Disease-free survival (minimum follow-up of 2 years) was 84% (21/25) among node-positive patients compared with 95% (18/19) for node-negative patients (P greater than 0.1, two-tailed test). These results contrast with the results from two other centers in which lymph node involvement was a significant adverse prognostic indicator. The use of intensive multimodal therapy including surgical resection of the primary tumor, wide-field radiation therapy to the tumor bed and regional lymph nodes, and chemotherapy may have accounted for the better survival in our node-positive patients.
关于区域局限性神经母细胞瘤（埃文斯分期II - III期）中淋巴结转移的预后和治疗意义的数据很少。我们分析了淋巴结状态以评估淋巴结受累的意义。淋巴结阳性患者的无病生存率（最短随访2年）为84%（21/25），而淋巴结阴性患者为95%（18/19）（P>0.1，双侧检验）。这些结果与其他两个中心的结果形成对比，在这两个中心，淋巴结受累是一个显著的不良预后指标。使用包括原发肿瘤手术切除、对肿瘤床和区域淋巴结进行广野放射治疗以及化疗在内的强化多模式治疗，可能是我们淋巴结阳性患者生存率较高的原因。
