高选择性迷走神经切断术对大鼠小肠钙转运的影响。

Effects of highly selective vagotomy on small intestinal calcium transport in the rat.

作者信息

Engelhardt W, Rümenapf G, Schwille P O

出版信息

Miner Electrolyte Metab. 1984;10(4):239-43.

Abstract

In parathyroid-intact and parathyroidectomized rats we studied the influence of highly selective vagotomy (HSV) on net absorption and bidirectional (lumen-to-plasma, LP; plasma-to-lumen, PL) calcium (Ca) fluxes in the duodenum and ileum. In parathyroid-intact rats, Ca fluxes in the duodenum and ileum are not significantly altered by HSV. Nevertheless, net absorption is increased in the duodenum and decreased in the ileum. In parathyroidectomized rats duodenal LP flux is reduced and ileal PL flux is increased, by HSV, with the result that there is a decrease in the net absorption in both intestinal segments. It is suggested that (1) in intact rats, the influence of HSV on the net absorption of Ca is different in the duodenum and the ileum; (2) after prior parathyroidectomy, HSV is potentially harmful to the Ca balance of the body, and (3) the mineral metabolic effects of HSV have so far not been adequately studied.

摘要

在甲状旁腺完整和甲状旁腺切除的大鼠中，我们研究了高选择性迷走神经切断术（HSV）对十二指肠和回肠钙（Ca）净吸收以及双向（肠腔至血浆，LP；血浆至肠腔，PL）钙通量的影响。在甲状旁腺完整的大鼠中，十二指肠和回肠中的钙通量不会因HSV而发生显著改变。然而，十二指肠中的净吸收增加，而回肠中的净吸收减少。在甲状旁腺切除的大鼠中，HSV会降低十二指肠的LP通量并增加回肠的PL通量，结果两个肠段的净吸收均减少。研究表明：（1）在完整大鼠中，HSV对十二指肠和回肠中钙净吸收的影响不同；（2）甲状旁腺切除术后，HSV可能对机体的钙平衡有害；（3）迄今为止，HSV对矿物质代谢的影响尚未得到充分研究。