Puschett J B, McGowan J, Fragola J, Chen T C, Keutmann H, Rosenblatt M
Miner Electrolyte Metab. 1984;10(4):271-4.
Acute clearance studies were performed in chronically thyroparathyroidectomized dogs to determine similarities and differences between the effects of 1-34 and 1-84 parathyroid hormone (PTH) on urinary calcium excretion. In a small (physiological) dose, 1-84 PTH caused no mean change in percentage calcium excretion, while the 1-34 fragment was frankly calciuric. At this dose, the two hormone preparations were equally phosphaturic. Fragments of PTH in the range 25-84 did not alter calcium or phosphate transport. We conclude that the entire molecule is required in order for the distal nephron effect of the hormone to enhance net calcium transport in the kidney to become manifest.
对长期进行甲状腺甲状旁腺切除的犬进行急性清除研究，以确定1-34和1-84甲状旁腺激素（PTH）对尿钙排泄影响的异同。小剂量（生理剂量）的1-84 PTH对钙排泄百分比无明显平均变化，而1-34片段则明显增加尿钙排泄。在此剂量下，两种激素制剂的排磷作用相同。25-84范围内的PTH片段不会改变钙或磷的转运。我们得出结论，为使激素在远端肾单位增强肾脏净钙转运的作用得以显现，需要完整的分子。
