Sher J H, Dixon W S
Can J Ophthalmol. 1982 Jun;17(3):116-20.
The suitability and effectiveness of hydrophilic soft contact lenses and donor corneal buttons for interlamellar refractive keratoplasty were evaluated in a study with rabbits. In each experimental eye a trephined button of Bausch & Lomb Soflens (polymacon), Cooper Permalens (perfilcon A) or rabbit cornea 6.5 mm in diameter was inserted in a corneal pocket created with a lamellar dissector. Among the inserts available for long-term follow-up all five of the Soflens inserts showed "melting" (perforation and sloughing) by 3 weeks, whereas six of the seven Permalens inserts and all four of the donor corneal inserts were clear at 3 to 6 months. Myopia was induced and the corneal curvature steepened with all but the high-minus Soflens inserts. Thus, interlamellar refractive keratoplasty with soft contact lenses of high water content or lathe-cut donor corneal buttons has potential for the correction of aphakia in rabbits and may well have similar potential in humans.
在一项针对兔子的研究中，评估了亲水性软性隐形眼镜和供体角膜纽扣用于板层屈光性角膜移植术的适用性和有效性。在每只实验眼中，将直径6.5毫米的博士伦Soflens（聚甲丙烯酸羟乙酯）、库珀Permalens（聚甲基丙烯酸甲酯A）或兔角膜制成的环钻纽扣插入用板层剥离器制作的角膜袋中。在可进行长期随访的植入物中，所有五个Soflens植入物在3周时均出现“融化”（穿孔和脱落），而七个Permalens植入物中的六个以及所有四个供体角膜植入物在3至6个月时均保持清晰。除高度数的Soflens植入物外，其他植入物均诱发了近视并使角膜曲率变陡。因此，使用高含水量软性隐形眼镜或车床切割的供体角膜纽扣进行板层屈光性角膜移植术有可能矫正兔子的无晶状体状态，在人类中可能也有类似的潜力。
