氟代 N-亚硝胺。4. N-亚硝基二丁胺及三种氟化类似物在两种细菌体系中的比较遗传毒性活性。

Fluoro-substituted N-nitrosamines. 4. Comparative genotoxic activities of N-nitrosodibutylamine and three fluorinated analogues in two bacterial systems.

作者信息

Pool B L, Janzowski C, Eisenbrand G, Preussmann R

出版信息

Carcinogenesis. 1982;3(7):781-4. doi: 10.1093/carcin/3.7.781.

DOI:10.1093/carcin/3.7.781

Abstract

N-Nitrosodibutylamine (NDBA) and three fluorinated analogues (N-nitroso (4,4,4-trifluorobutyl-amine, F3NDBA; N-nitrosobis (4,4,4-trifluorobutyl)amine, F6NDBA; and N-nitrosobis (2,2,3,3,4,4,4-heptafluorobutyl) amine, F14NDBA were comparatively investigated for biological activity in two bacterial systems. Opposite orders of magnitude were obtained for their potency in the two tests. For inducing his+ reversion in auxotrophic strains of Salmonella typhimurium the sequence was F3NDBA greater than F6NDBA greater than NDBA and for inducing lethal DNA damage in repair deficient strains of Escherichia coli WP2 it was NDBA greater than F6NDBA. F14NDBA was not active in either test system.

摘要

对N-亚硝基二丁胺（NDBA）及其三种氟化类似物（N-亚硝基（4,4,4-三氟丁基）胺，F3NDBA；N-亚硝基双（4,4,4-三氟丁基）胺，F6NDBA；以及N-亚硝基双（2,2,3,3,4,4,4-七氟丁基）胺，F14NDBA）在两种细菌系统中的生物活性进行了比较研究。在两项测试中，它们的效力获得了相反的数量级。在鼠伤寒沙门氏菌营养缺陷型菌株中诱导his+回复突变时，顺序为F3NDBA > F6NDBA > NDBA；而在大肠杆菌WP2修复缺陷型菌株中诱导致死性DNA损伤时，顺序为NDBA > F6NDBA。F14NDBA在任一测试系统中均无活性。