Quirk J G, Bowes W A
Clin Perinatol. 1982 Jun;9(2):363-80.
All physicians responsible for the care of gravidae at high risk for preterm labor and delivery must be expert in the management of these pregnancies. Only a fraction of women who present in labor remote from term are candidates for long-term tocolysis. Whatever treatment regimen is utilized, the clinician must be familiar with their risks as well as their benefits. The majority of women who present with preterm labor will require delivery or will deliver despite efforts to the contrary. If delivery is imminent or indicated, intensive intrapartum monitoring of these fetuses, especially those weighing less than 1500 gm, is mandatory. The mother should be transferred to a facility that contains both expert obstetric care and a neonatal intensive care unit staffed with individuals experienced in the management of these very low birth weight infants. Attempts at pharmacologic induction of lung maturation should be reserved for those situations in which: (1) the fetal membranes are intact, (2) the fetal lungs are likely to be immature, (3) delivery of the infant may be delayed without undue risk for 48 hours following initiation of therapy, and finally, (4) the informed consent of the parents has been obtained. (By the same token, the probable efficacy of glucocorticoids should not serve as license to deliver the preterm infant.) Preterm infants are viable, even at 25 to 26 weeks of gestation, provided that labor and delivery are managed expertly. When vaginal delivery is contemplated, labor, if induced, should not be forceful. Fetal heart rate and uterine contractions should be monitored continuously. Evidence of fetal jeopardy must be dealt with expeditiously. Nontraumatic delivery, including the liberal use of cesarean section, into the hands of an experienced neonatologist will reduce the number of asphyxiated premature infants and, therefore, the risk of hyaline membrane disease. For the very low birth weight infant presenting as a breech, abdominal delivery is recommended. It is important that the uterine incision, regardless of type, be large enough to allow for nontraumatic delivery of the infant. If greater improvements in the survival and outcome of low birth weight infants are to continue, it is mandatory that there be close collaboration not only between obstetrician and pediatrician, but also between all physicians and nursing staff who care for this group of high-risk patients.
所有负责护理有早产和分娩高风险孕妇的医生都必须精通此类妊娠的管理。只有一小部分在离足月较远时出现临产症状的女性才适合进行长期的宫缩抑制治疗。无论采用何种治疗方案,临床医生都必须熟悉其风险和益处。大多数出现早产症状的女性,无论采取何种相反措施,都将需要分娩或最终分娩。如果分娩迫在眉睫或有指征,对这些胎儿,尤其是体重不足1500克的胎儿进行强化产时监测是必不可少的。母亲应被转至具备专业产科护理以及配备有管理这些极低出生体重儿经验丰富人员的新生儿重症监护病房的机构。药物诱导肺成熟的尝试应仅限于以下情况:(1)胎膜完整;(2)胎儿肺部可能不成熟;(3)在开始治疗后,婴儿分娩可延迟48小时而无不当风险;最后,(4)已获得父母的知情同意。(同样,糖皮质激素的可能疗效不应成为早产婴儿分娩的许可证。)早产婴儿即使在妊娠25至26周时也是有存活能力的,前提是分娩过程得到专业管理。当考虑经阴道分娩时,如果是诱导分娩,不应强行进行。应持续监测胎儿心率和子宫收缩情况。必须迅速处理胎儿窘迫的证据。由经验丰富的新生儿科医生进行无创分娩,包括广泛使用剖宫产,将减少窒息早产婴儿的数量,从而降低透明膜病的风险。对于以臀位呈现的极低出生体重婴儿,建议进行剖宫产。无论何种类型的子宫切口,足够大以允许无创分娩婴儿很重要。如果要继续提高低出生体重婴儿的存活率和结局,不仅产科医生和儿科医生之间,而且所有照顾这组高危患者的医生和护理人员之间必须密切合作,这是必不可少的。