部分肝切除术后年轻和老年大鼠肝脏微粒体的数量及翻译效率

Quantity and translation efficiency of liver microsomes in young and old rats following partial hepatectomy.

Mallonee R L, Garrison N E, Sellers C M

Comp Biochem Physiol B. 1982;72(2):275-81. doi: 10.1016/0305-0491(82)90046-3.

Abstract

Liver microsomal quantity decreased in young rats 2 days after partial hepatectomy or sham operation, increased to preoperative values by 8 days, and remained unchanged 16 days following surgery. 2. In old rats, microsomal quantity remained unchanged following surgery, but increased in sham-operated controls. 3. Translational efficiency of microsomes from young, sham-operated animals was unaffected, but decreased 2 days after partial hepatectomy. 4. In old, sham-operated controls, efficiency decreased, but remained unchanged 2 days after partial hepatectomy. 5. Eight and 16 days after surgery, efficiency of microsomes from young and old animals appeared indistinguishable, and were similar to those of adults before surgery.

摘要

部分肝切除或假手术后2天，幼鼠肝脏微粒体数量减少，8天时增加至术前水平，术后16天保持不变。2. 老龄大鼠术后微粒体数量保持不变，但假手术对照组增加。3. 幼龄假手术动物的微粒体翻译效率未受影响，但部分肝切除术后2天降低。4. 在老龄假手术对照组中，效率降低，但部分肝切除术后2天保持不变。5. 术后8天和16天，幼龄和老龄动物的微粒体效率无明显差异，且与术前成年动物相似。