Zimmermann H
Eur J Pediatr. 1982 May;138(3):258-62. doi: 10.1007/BF00441213.
Progressive pulmonary interstitial lobar emphysema is a complication of artificial ventilation in premature infants with RDS. Three cases are presented who developed a progressive form of PIPE. It is demonstrated that PIPE is caused by air escaping through alveolar leaks into the pulmonary lymphatic capillary system causing dilation of lymphatic channels. Because of its increasing compressive effect on adjacent lung areas PIPE requires rapid and effective therapy. Although several types of conservative approach are suggested, lobectomy is not indicated when prolonged ventilation with high pressures and high concentrations of oxygen have caused severe bronchopulmonary dysplasia.
进行性肺间质性大叶肺气肿是患有呼吸窘迫综合征的早产儿人工通气的一种并发症。本文报告了3例发生进行性PIPE的病例。结果表明，PIPE是由于空气通过肺泡渗漏进入肺淋巴毛细血管系统，导致淋巴管扩张所致。由于其对相邻肺区的压迫作用不断增加，PIPE需要快速有效的治疗。尽管提出了几种保守治疗方法，但当高压和高浓度氧气的长时间通气导致严重支气管肺发育不良时，不建议进行肺叶切除术。
