Lumley P, Humphrey P P, Kennedy I, Coleman R A
Eur J Pharmacol. 1982 Jul 16;81(3):421-30. doi: 10.1016/0014-2999(82)90107-8.
Following close intra-arterial administration to the carotid and femoral arterial beds of the anaesthetised dog the rank order of potency for producing vasodilation was PGE greater than 11-deoxy PGE0 greater than PGA greater than PGI2 greater than PGB with the 1- and 2-series prostaglandins equipotent. PGI2 was about 60 times weaker than PGE1. In the mesenteric arterial bed the rank order of potency for producing vasodilation was the same except PGI2 was about equipotent with PGE1. The absolute potency of the prostaglandins, with the exception of PGI, was similar on all three vascular beds. A similar differential action of PGI2 relative to PGE1 was also observed following both left intraventricular and intravenous administration. We suggest that all three arterial beds contain PGE-receptors mediating vasodilatation at which the E-series prostaglandins are potent and PGI2 is weak. In addition the mesenteric bed contains PGI2-receptors which are absent or sparse in the carotid and femoral beds.
在对麻醉犬的颈动脉和股动脉床进行动脉内近距离给药后，产生血管舒张作用的效力顺序为：前列腺素E（PGE）＞11-脱氧前列腺素E0（11-deoxy PGE0）＞前列腺素A（PGA）＞前列环素（PGI2）＞前列腺素B（PGB），1-系列和2-系列前列腺素效力相当。前列环素（PGI2）的效力约为前列腺素E1（PGE1）的1/60。在肠系膜动脉床，产生血管舒张作用的效力顺序相同，只是前列环素（PGI2）与前列腺素E1（PGE1）效力相当。除前列环素（PGI）外，前列腺素在所有三个血管床上的绝对效力相似。在左心室内给药和静脉给药后，也观察到前列环素（PGI2）相对于前列腺素E1（PGE1）有类似的差异作用。我们认为，所有三个动脉床都含有介导血管舒张的前列腺素E（PGE）受体，E-系列前列腺素对其有强效作用，而前列环素（PGI2）作用较弱。此外，肠系膜床含有前列环素（PGI2）受体，而颈动脉和股动脉床中该受体缺乏或稀少。
