Spence M R, King T M, Burkman R T, Atienza M F
Obstet Gynecol. 1982 Oct;60(4):502-5.
A randomized prospective double-blind study was conducted to determine the efficacy of prophylactic antibiotics as compared with placebo in 198 women undergoing second-trimester intraamniotic injection abortions. Patients received either sodium cephalothin or placebo intravenously before the procedure and for up to 8 additional doses. In 11 patients postabortion endometritis developed; 2 had received the antibiotic and 9 had received a placebo (P less than .05). Prophylactic cephalothin decreased the incidence of endometritis in patients undergoing midtrimester injection abortion. An injection-abortion interval greater than 24 hours appears to identify patients at risk for the development of postabortion endometritis.
进行了一项随机前瞻性双盲研究，以确定预防性抗生素与安慰剂相比，对198例接受孕中期羊膜腔内注射堕胎术的妇女的疗效。患者在手术前静脉注射头孢噻吩钠或安慰剂，并最多额外注射8剂。11例患者术后发生子宫内膜炎；2例接受了抗生素治疗，9例接受了安慰剂治疗（P<0.05）。预防性使用头孢噻吩降低了接受孕中期注射堕胎术患者子宫内膜炎的发生率。注射堕胎间隔时间大于24小时似乎可识别出有发生堕胎后子宫内膜炎风险的患者。
