Jialal I, Joubert S M
S Afr Med J. 1982 Oct 9;62(16):549-52.
Cortisol and growth hormone (GH) responses to a 100 g oral glucose load were measured in 85 Indian patients with non-insulin-dependent diabetes in the young (NIDDY) and 50 reference subjects; in 16 patients and 12 reference subjects the glucagon responses were also assessed. Fasting serum cortisol and plasma glucagon levels were significantly higher in the NIDDY group (P less than 0.001); in contrast, GH levels in the NIDDY patients were significantly lower (P less than 0.01). Plasma glucagon was only significantly suppressed 150 minutes after oral glucose loading in the NIDDY group, in contrast to the reference group, which showed maximum suppression at 90 minutes; at all time intervals plasma glucagon levels were significantly higher in the NIDDY patients. Obesity did not affect fasting plasma glucagon levels. In response to the oral glucose load serum cortisol levels in the NIDDY patients were suppressed in parallel with those in the reference group but remained significantly higher throughout the period of observation at all time intervals. Obese NIDDY patients had higher fasting cortisol levels, but their response to orally administered glucose was no different from that of the NIDDY group as a whole. GH suppression by oral glucose in NIDDY patients was less than that in the reference group, and the rebound rise occurred earlier. Obese NIDDY patients had higher fasting GH levels than their non-obese counterparts, but responses to the glucose load were not different.
对85名印度青年非胰岛素依赖型糖尿病患者（NIDDY）和50名对照受试者测量了口服100克葡萄糖负荷后皮质醇和生长激素（GH）的反应；对16名患者和12名对照受试者还评估了胰高血糖素的反应。NIDDY组空腹血清皮质醇和血浆胰高血糖素水平显著更高（P<0.001）；相比之下，NIDDY患者的GH水平显著更低（P<0.01）。与在90分钟时出现最大抑制的对照组相比，NIDDY组仅在口服葡萄糖负荷后150分钟时血浆胰高血糖素才被显著抑制；在所有时间点，NIDDY患者的血浆胰高血糖素水平均显著更高。肥胖不影响空腹血浆胰高血糖素水平。口服葡萄糖负荷后，NIDDY患者的血清皮质醇水平与对照组平行受到抑制，但在整个观察期内所有时间点均显著更高。肥胖的NIDDY患者空腹皮质醇水平更高，但其对口服葡萄糖的反应与整个NIDDY组并无差异。NIDDY患者口服葡萄糖后对GH的抑制作用小于对照组，且反弹升高出现得更早。肥胖的NIDDY患者空腹GH水平高于非肥胖患者，但其对葡萄糖负荷的反应并无差异。
