Prowse C V, Dawes J, Lane D A, Ireland H, Knight I
Thromb Res. 1982 Jul 1;27(1):91-7. doi: 10.1016/0049-3848(82)90282-1.
Changes in immunoreactive fibrinopeptide A, fragment B beta 1-42 and fragment E were followed after major and minor in vivo plasminogen activation, after infusion of streptokinase and acylated streptokinase-plasminogen complex respectively, in healthy male volunteers. Major activation resulted in a dramatic rise in all three peptides, fragment E persisting in the circulation longest. Fragment B beta 1-42 was also markedly increased after minor systemic plasminogen activation despite apparently adequate levels of immediate antiplasmin.
在健康男性志愿者体内，分别输注链激酶和酰化链激酶 - 纤溶酶原复合物，引发体内纤溶酶原主要和次要激活后，对免疫反应性纤维蛋白肽A、Bβ1 - 42片段和E片段的变化进行了跟踪研究。主要激活导致所有这三种肽显著升高，E片段在循环中持续时间最长。尽管即时抗纤溶酶水平看似充足，但次要全身性纤溶酶原激活后，Bβ1 - 42片段也显著增加。
