Serebriakova T N, Andreenko G V, Tsymanovich S G, Maksimova R A, Sharkova T S
Nauchnye Doki Vyss Shkoly Biol Nauki. 1985(2):66-71.
It has been established that fibrinolytically active enzyme longolytine isolated from the culture fluid of the saprophyte fungus Arthrobotrys longa at intravenous injection favours the prolonged increase of the plasma fibrinolytic properties as well as activation of endogenic plasminogen. Maximum values of fibrinolytic activity have been marked in 5 and 30 min after enzyme intravenous injection. The plasminogen activity is high in 120 min. The fibrinolysis indexes--fibrinolytic activity of the euglobulin fraction and amount of plasminogen activator--in 3,5 and 5 times higher than in vitro at intravenous injection. The activation of coagulation system does not occur.
已经确定，从腐生真菌长柄节丛孢菌培养液中分离出的具有纤溶活性的酶longolytine静脉注射后，有利于血浆纤溶特性的长期增加以及内源性纤溶酶原的激活。酶静脉注射后5分钟和30分钟时纤溶活性达到最大值。120分钟时纤溶酶原活性较高。纤溶指标——优球蛋白组分的纤溶活性和纤溶酶原激活剂的量——在静脉注射时比体外高3、5和5倍。凝血系统未被激活。
