四氧化锇和198金对正常及关节炎兔膝关节的影响。

Effect of osmium tetroxide and 198Au in normal and arthritic rabbit knee joints.

作者信息

Ahlberg K M, Henricson A S, Telhag H T, Wollheim F A

出版信息

Scand J Rheumatol. 1978;7(1):21-5.

Abstract

Antigen-induced arthritis (AIA) was induced in adult rabbit knee joints, using ovalbumin as antigen. After 4 weeks, intra-articular injections of 0.3 ml 1% osmium tetroxide or 100 muCi 198Au were given. The same injections were also given to normal animals. The animals were observed for up to 12 weeks. In the normal animals, no affection of articular cartilage could be seen by light microscopy. In the arthritic animals, however, severe destruction of articular cartilage was seen. The degree of destruction in the osmium tetroxide-treated animals was similar to or even worse than that of the controls, whereas the 198Au-treated animals showed a lesser degree of destruction than both controls and osmium tetroxide-treated animals. Autoradiograms, using 3H-thymidine, showed affection articular cartilage in all groups, i.e. both normal and arthritic.

摘要

以卵清蛋白作为抗原，在成年兔膝关节诱导出抗原诱导性关节炎（AIA）。4周后，关节腔内注射0.3毫升1%的四氧化锇或100微居里的198金。同样的注射也给予正常动物。对动物观察长达12周。在正常动物中，光镜下未见关节软骨有病变。然而，在患关节炎的动物中，可见关节软骨严重破坏。四氧化锇处理组动物的破坏程度与对照组相似甚至更严重，而198金处理组动物的破坏程度低于对照组和四氧化锇处理组动物。使用3H-胸腺嘧啶核苷的放射自显影片显示，所有组（即正常组和关节炎组）的关节软骨均有病变。