Ebert C D, Lee E S, Kim S W
J Biomed Mater Res. 1982 Sep;16(5):629-38. doi: 10.1002/jbm.820160510.
Owing to the chemical instability of prostacyclin, the direct immobilization of this prostaglandin has not been successful. A new procedure is described for the preparation of immobilized prostacyclin based on the conversion of immobilized prostaglandin F2 alpha to immobilized prostaglandin I2-Materials thus prepared show dramatic antiplatelet effects with regard to platelet aggregation and platelet adhesion. Radioimmunoassays of plasmas used in in vitro platelet tests and of buffers used in prostacyclin leakage studies established that these effects are not due to the release of prostacyclin from the respective immobilization substrates.
由于前列环素的化学不稳定性，直接固定这种前列腺素尚未成功。本文描述了一种基于将固定化前列腺素F2α转化为固定化前列腺素I2来制备固定化前列环素的新方法。由此制备的材料在血小板聚集和血小板黏附方面显示出显著的抗血小板作用。对体外血小板测试中使用的血浆以及前列环素泄漏研究中使用的缓冲液进行放射免疫测定表明，这些作用并非由于前列环素从各自的固定化底物中释放所致。
