Kuhn J J, Hendley J O, Adams K F, Clark J W, Gwaltney J M
Chest. 1982 Dec;82(6):713-8. doi: 10.1378/chest.82.6.713.
The efficacy of guaifenesin in reducing cough frequency in young adults with acute respiratory disease was evaluated by both an objective cough counting system and a questionnaire. A guaifenesin cough preparation and the syrup vehicle were administered in a double-blind manner. Coughs were recorded on tape over a 24-hour baseline evaluation period and a 36-hour treatment period for 42 patients. A pronounced diurnal variation in cough frequency was observed. The evaluation of efficacy was based upon comparisons between equivalent six-hour time periods of successive days. No antitussive effect of guaifenesin was demonstrated. The questionnaire was administered to 65 patients, including the 42 whose coughs were recorded. Of 26 patients with productive cough receiving guaifenesin, 25 (96 percent) reported a decrease in sputum thickness compared to 13 (54 percent) of 24 patients receiving the vehicle (p = 0.01, Fisher exact test). Twenty-three of 26 (88 percent) patients receiving guaifenesin also reported reduction in sputum quantity compared to 15 of 24 (62.5 percent) receiving the vehicle (p = 0.07, Fisher exact test). The diurnal variation in cough frequency measured by the tape recording was not apparent from the subjective cough frequency estimates obtained by the questionnaire.
通过客观咳嗽计数系统和问卷调查对愈创甘油醚在减轻急性呼吸道疾病年轻成人咳嗽频率方面的疗效进行了评估。以双盲方式给予愈创甘油醚止咳制剂和糖浆赋形剂。对42例患者在24小时基线评估期和36小时治疗期内的咳嗽情况进行录音记录。观察到咳嗽频率有明显的昼夜变化。疗效评估基于连续几天等效六小时时间段之间的比较。未证明愈创甘油醚有镇咳作用。对65例患者进行了问卷调查，包括咳嗽被记录的42例。在26例接受愈创甘油醚治疗的有痰咳嗽患者中，25例（96%）报告痰液黏稠度降低，相比之下，接受赋形剂治疗的24例患者中有13例（54%）报告痰液黏稠度降低（p = 0.01，Fisher精确检验）。26例接受愈创甘油醚治疗的患者中有23例（88%）还报告痰量减少，相比之下，接受赋形剂治疗的24例患者中有15例（62.5%）报告痰量减少（p = 0.07，Fisher精确检验）。通过问卷调查获得的主观咳嗽频率估计中，未发现录音测量的咳嗽频率昼夜变化。
