Chaudhuri G, Barone P, Lianos E, Hurd M, Lele A, Venuto R
Am J Obstet Gynecol. 1982 Dec 1;144(7):760-7. doi: 10.1016/0002-9378(82)90348-9.
The concentrations of prostaglandin E2 (PGE2) and prostacyclin (PGI2) were estimated in blood obtained from the uterine venous effluent and a peripheral artery of conscious pregnant and nonpregnant rabbits. The blood was analyzed both with a superfusion bioassay and radioimmunoassays. PGE2, but not PGI2, was detected in a very high concentration in the uterine venous effluent of the pregnant rabbit. The peripheral blood of pregnant animals also revealed increased levels of only PGE2. The results of both assay techniques correlated closely. These studies suggest that the uteroplacental unit is the source of the increased peripheral level of the potent vasodilator PGE2. In contrast, these data fail to support the notion that PGI2 is the primary systemic-acting vasodepressor prostaglandin in rabbit pregnancy.
在清醒的怀孕和未怀孕兔子的子宫静脉流出液和外周动脉采集的血液中，对前列腺素E2（PGE2）和前列环素（PGI2）的浓度进行了测定。血液通过灌注生物测定法和放射免疫测定法进行分析。在怀孕兔子的子宫静脉流出液中检测到高浓度的PGE2，但未检测到PGI2。怀孕动物的外周血中也仅显示PGE2水平升高。两种测定技术的结果密切相关。这些研究表明，子宫胎盘单位是强效血管舒张剂PGE2外周水平升高的来源。相比之下，这些数据不支持PGI2是兔子怀孕时主要的全身作用血管舒张前列腺素这一观点。
