Baron M D, Sönksen P H
Biosci Rep. 1982 Oct;2(10):785-93. doi: 10.1007/BF01114938.
We have identified and isolated two forms of insulin receptor from rat-liver plasma membranes. The smaller (Mr = 90k) is a single polypeptide. The same polypeptide appears to be the insulin-binding site of the larger Mr = 280k). Only the larger, multisubunit, receptor shows high-affinity binding of insulin and negative cooperativity in its dissociation kinetics.
我们已从大鼠肝脏质膜中鉴定并分离出两种形式的胰岛素受体。较小的一种（Mr = 90k）是单一多肽。同一多肽似乎是较大的Mr = 280k）胰岛素受体的胰岛素结合位点。只有较大的多亚基受体在其解离动力学中显示出胰岛素的高亲和力结合和负协同性。
