Vogler W R
Prog Clin Biol Res. 1982;106:1-13.
In conclusion, the development of the cell separator which can isovolumetrically remove specific components from the blood has opened a new avenue of research and therapy for patients with a variety of disorders. The techniques are relatively safe and rapid, but still exceedingly expensive. The indications and efficacy of cytapheresis appear relatively clear. The role of lymphocytapheresis in various disease states is still under investigation. Plasma exchange currently must be considered a palliative procedure, but clear and prolonged benefit has resulted in a few instances. The expense will not make this a practical approach in many instances. A combination of immunosuppressive therapy with plasma exchange will evolve as a more appropriate treatment in many instances. Finally, the removal of specific substances from the plasma by immunoadsorption columns should have the advantage of less side effects, less depletion of normal elements of the plasma, and more specifically targeted therapy.
总之，能够等容性地从血液中去除特定成分的细胞分离器的研发，为患有各种病症的患者开辟了新的研究和治疗途径。这些技术相对安全且快速，但仍然极其昂贵。血细胞分离术的适应症和疗效似乎比较明确。淋巴细胞分离术在各种疾病状态下的作用仍在研究中。目前，血浆置换必须被视为一种姑息性治疗方法，但在少数情况下已产生了明确且持久的益处。在许多情况下，费用使其无法成为一种切实可行的方法。在许多情况下，免疫抑制疗法与血浆置换相结合将演变成一种更合适的治疗方法。最后，通过免疫吸附柱从血浆中去除特定物质应具有副作用更少、血浆正常成分消耗更少以及治疗更具针对性的优势。
