Puri S K, Kazim M, Dutta G P
Trans R Soc Trop Med Hyg. 1982;76(5):650-1. doi: 10.1016/0035-9203(82)90234-6.
A strain of Plasmodium berghei made resistant to a 244 mg/kg daily dose of mefloquine by interrupted subcurative therapy in successive passages in weanling rats, was maintained for more than six months under drug pressure and was cryopreserved. Experiments with this strain have shown its loss of virulence for intact mice. In splenectomized Swiss mice infection with this resistant strain is transient. The mefloquine resistance of this line was unstable and the strain became sensitive to mefloquine after 10 serial drug-free passages but did not recover its infectivity to mice.
通过在断奶大鼠中连续传代进行间断性亚治疗剂量给药，使伯氏疟原虫对每日244毫克/千克的甲氟喹产生抗性，该菌株在药物压力下维持了六个多月并进行了冷冻保存。用该菌株进行的实验表明，它对完整小鼠的毒力有所丧失。在脾切除的瑞士小鼠中，感染这种抗性菌株是短暂的。该品系对甲氟喹的抗性不稳定，在连续10次无药传代后，该菌株对甲氟喹变得敏感，但未恢复对小鼠的感染性。
