Lang D A, Matthews D R, Burnett M, Ward G M, Turner R C
Diabetes. 1982 Jan;31(1):22-6. doi: 10.2337/diab.31.1.22.
The basal plasma insulin, glucagon, and glucose concentrations of 28 normal subjects were measured at 1-min intervals for periods of 45-120 min. Regular plasma insulin and/or glucagon cycles were detected in 11 subjects by autocorrelation (mean periods 13.1 and 13.7 min, respectively). Individual plasma insulin cycles were defined in all subjects (mean period 10.7 min, amplitude 1.1 mU/L), and were associated, after averaging, with plasma glucagon (amplitude 5.5 pg/ml) and plasma glucose (0.02 mmol/L) cycles. There was a significant correlation between the amplitudes of simultaneous plasma insulin and glucagon cycles (r = 0.23, P = less than 0.05, N = 124). Cross-correlation demonstrated a delay of 2 min between the changes in plasma insulin and glucagon. No comparable oscillations in plasma pancreatic polypeptide were detected. The synchronous pulsatile secretion of glucagon and insulin may be a mechanism by which insulin's hepatic effects are limited, thereby maintaining hepatic glucose production but allowing sufficient peripheral insulin concentrations to inhibit excessive catabolism. The simultaneous pulses of insulin and glucagon may be stimulated by a pacemaker, with the A-B intercellular connections producing insulin and glucagon synchrony.
对28名正常受试者的基础血浆胰岛素、胰高血糖素和葡萄糖浓度每隔1分钟测量一次，持续45 - 120分钟。通过自相关在11名受试者中检测到规律的血浆胰岛素和/或胰高血糖素周期（平均周期分别为13.1分钟和13.7分钟）。在所有受试者中定义了个体血浆胰岛素周期（平均周期10.7分钟，振幅1.1 mU/L），平均后与血浆胰高血糖素（振幅5.5 pg/ml）和血浆葡萄糖（0.02 mmol/L）周期相关。同时出现的血浆胰岛素和胰高血糖素周期的振幅之间存在显著相关性（r = 0.23，P < 0.05，N = 124）。互相关显示血浆胰岛素和胰高血糖素变化之间有2分钟的延迟。未检测到血浆胰多肽有类似的振荡。胰高血糖素和胰岛素的同步脉冲分泌可能是一种机制，通过该机制胰岛素的肝脏作用受到限制，从而维持肝脏葡萄糖生成，但允许足够的外周胰岛素浓度抑制过度分解代谢。胰岛素和胰高血糖素的同时脉冲可能由起搏器刺激，A - B细胞间连接产生胰岛素和胰高血糖素的同步性。
