Doberne L, Greenfield M S, Rosenthal M, Widstrom A, Reaven G
Diabetes. 1982 May;31(5 Pt 1):396-400. doi: 10.2337/diab.31.5.396.
Two insulin clamp studies were performed at different steady-state plasma glucose concentrations in 13 patients with non-insulin-dependent diabetes mellitus (NIDDM). Steady-state plasma insulin concentrations were comparable, with mean +/- SEM levels of 94 +/- 3 and 95 +/- 4 muU/ml being achieved during the two studies. Glucose utilization rate (M) varied directly with plasma glucose concentration in each subject. Thus, the mean +/- SEM value of M was 4.92 +/- 0.73 mg/kg/min when patients were studied at a mean +/- SEM plasma glucose concentration of 226 +/- 15 mg/dl, and M was 2.71 mg/kg/min when the same subjects were studied at a glucose concentration of 118 +/- 6 mg/dl. In contrast, the values for glucose metabolic clearance rate (MCR), which were 2.35 +/- 0.50 and 2.49 +/- 0.47 ml/kg/min, respectively, during the two studies, did not vary significantly with plasma glucose concentration. These data indicate that the glucose metabolic clearance rate (MCR), but not glucose utilization rate (M), can be used to compare in vivo insulin action when insulin clamp studies are performed in subjects with different basal plasma glucose concentrations.
对13例非胰岛素依赖型糖尿病（NIDDM）患者在不同的稳态血浆葡萄糖浓度下进行了两项胰岛素钳夹研究。稳态血浆胰岛素浓度相当，两项研究期间平均±标准误水平分别为94±3和95±4 μU/ml。每个受试者的葡萄糖利用率（M）与血浆葡萄糖浓度直接相关。因此，当患者在平均±标准误血浆葡萄糖浓度为226±15 mg/dl时进行研究，M的平均±标准误值为4.92±0.73 mg/kg/min，而当相同受试者在葡萄糖浓度为118±6 mg/dl时进行研究，M为2.71 mg/kg/min。相比之下，两项研究期间葡萄糖代谢清除率（MCR）的值分别为2.35±0.50和2.49±0.47 ml/kg/min，并未随血浆葡萄糖浓度显著变化。这些数据表明，当在具有不同基础血浆葡萄糖浓度的受试者中进行胰岛素钳夹研究时，葡萄糖代谢清除率（MCR）而非葡萄糖利用率（M）可用于比较体内胰岛素作用。
