Boyd C N, Ramberg R C, Thomas E D
Leuk Res. 1982;6(6):833-7. doi: 10.1016/0145-2126(82)90067-4.
A total of 243 patients with acute leukemia received a marrow graft from a donor of the opposite sex. Seventy-five patients subsequently relapsed, and specimens of the recurrent leukemia cells were available for cytogenetic analysis in 54. Three relapses were in donor-type cells. Four patients whose relapses were in host-type cells showed a cytogenic abnormality that differed from the original leukemic clone. We conclude that a 'new' leukemia in donor cells, and possibly in host cells, constitutes a small but significant fraction of recurrent leukemia after marrow grafting.
共有243例急性白血病患者接受了来自异性供体的骨髓移植。75例患者随后复发，其中54例有复发性白血病细胞标本可供细胞遗传学分析。3例复发为供体型细胞。4例复发为宿主型细胞的患者显示出与原始白血病克隆不同的细胞遗传学异常。我们得出结论，供体细胞中，可能还有宿主细胞中的“新”白血病，在骨髓移植后复发性白血病中占一小部分但比例显著。
