Torras H, Lecha M, Mascaró/ J M
Med Cutan Ibero Lat Am. 1982;10(2):103-112.
The authors summarize their experience in the treatment of recurrent, necrotic and giant mucocutaneous aphthosis (9 cases) and Behçet's disease (9 cases) with Thalidomide during four years. In recurrent mucocutaneous aphthosis the results were very good, with fast disappearance of pain, healing of the ahthae and disappearance or delay of recurrence. The result in Behçet's disease is similar, possibly less, in mucocutaneous lesions. Uveitis also reacts favorably but we can not say that the results were superior to those obtained by other drugs (corticoids, cytostatics immunosuppressives), although its side effects are less. On the other hand it does not appear to have any effect on other symptoms such as arthritis (in which colchicine is active), thromboflebitis or fever. There is not sufficient experience to judge its action on neurological symptoms. The recommended dose is 100 mgr./day for 10 days, a higher dose does not appear to give better results. Patients who have received treatment several times appear to have the same results, but slower. Neurotoxicity has not been observed and the only side effect which has been noted is digestive intolerance in two cases, after which the medication was stopped. The authors consider that Thalidomide, with due precaution, which must be scrupulously determined, is the most active medicament in particularly severe cases with profusion of necrotic aphthae, mutilating and recurring mucocutaneous aphthosis, also being useful in controlling some symptoms of Behçet's disease.
作者总结了他们在四年间用沙利度胺治疗复发性、坏死性及巨型黏膜皮肤型口疮（9例）和白塞病（9例）的经验。在复发性黏膜皮肤型口疮中，效果非常好，疼痛迅速消失，口疮愈合，复发消失或延迟。白塞病的结果类似，在黏膜皮肤病变方面可能稍逊一筹。葡萄膜炎也有良好反应，但我们不能说其结果优于其他药物（皮质类固醇、细胞抑制剂、免疫抑制剂）所取得的结果，尽管其副作用较少。另一方面，它似乎对其他症状如关节炎（秋水仙碱对其有效）、血栓性静脉炎或发热没有任何作用。判断其对神经症状的作用尚无足够经验。推荐剂量为每日100毫克，服用10天，更高剂量似乎不会产生更好的效果。多次接受治疗的患者似乎有相同的结果，但起效较慢。尚未观察到神经毒性，仅注意到两例出现消化不耐受，之后停药。作者认为，沙利度胺在采取必须严格确定的适当预防措施后，是治疗特别严重的伴有大量坏死性口疮、致残性复发性黏膜皮肤型口疮的最有效药物，对控制白塞病的某些症状也有用。
