Pradalier A, Dry J, Flouvat B, Decourt S, Fodor F
Pathol Biol (Paris). 1982 Dec;30(10):851-4.
In the purpose to evaluate the circadian changes of theophylline pharmacokinetic, 8 healthy subjects (age range 22-39 y, weight 54-91 kg) were given a single oral dose of 4,5 mg/kg theophylline solution. Administration was made randomly at 9 a.m. after 12 hours fasting and at 9 p.m. After evening administration the subjects remained awake during the night and a standardized meal was served 4 h and 9 h after theophylline intake. Plasma theophylline concentrations were measured by a high performance liquid chromatography. Absorption is significantly faster in the morning than in the evening but C max values were identical. Plasma elimination half-life is significantly different (8,01 +/- 1,95 h in the morning, 6,23 +/- 1,75 h in the evening). No significant modifications were observed of the area under the curve, the body clearance, the apparent volume of distribution. There were no differences in the total body clearance, the area under the concentration-time curve, the apparent volume of distribution.
为了评估茶碱药代动力学的昼夜变化，8名健康受试者（年龄范围22 - 39岁，体重54 - 91千克）口服单剂量4.5毫克/千克的茶碱溶液。给药在禁食12小时后的上午9点和晚上9点随机进行。晚上给药后，受试者夜间保持清醒，在摄入茶碱后4小时和9小时提供标准化餐食。血浆茶碱浓度通过高效液相色谱法测定。早晨的吸收明显比晚上快，但Cmax值相同。血浆消除半衰期有显著差异（上午为8.01±1.95小时，晚上为6.23±1.75小时）。曲线下面积、机体清除率、表观分布容积未观察到显著变化。总体清除率、浓度-时间曲线下面积、表观分布容积没有差异。
