Malaisse W J, Lebrun P, Herchuelz A
Pflugers Arch. 1982 Nov 11;395(3):201-3. doi: 10.1007/BF00584810.
A rise in extracellular glucose concentration from 8.3 to 16.7 mM stimulates both Ca2+ inflow and K+ exit in perfused rat pancreatic islets. These ionic changes are associated with an increase in bioelectrical spiking activity. From a quantitative analysis of 45Ca and 86Rb outflow from prelabelled islets, it is proposed that each electrical spike coincides, approximately, with the entry of 0.8 fmol of Ca2+ and exit of 3.6 fmol of K+ per mm2 of cell surface.
细胞外葡萄糖浓度从8.3毫摩尔升至16.7毫摩尔会刺激灌注大鼠胰岛中的钙离子流入和钾离子流出。这些离子变化与生物电尖峰活动的增加有关。通过对预先标记的胰岛中45钙和86铷流出的定量分析，提出每个电尖峰大约与每平方毫米细胞表面0.8飞摩尔钙离子的进入和3.6飞摩尔钾离子的流出同时发生。
