Martin M V, Dinsdale R C
Br J Oral Surg. 1982 Dec;20(4):294-8. doi: 10.1016/s0007-117x(82)80026-7.
Two cases of oral candidiasis are described which failed to respond to nystatin therapy when used in combination with triamcinolone acetonide. The isolates of C. albicans obtained from the patients after treatment showed high in vitro resistance to nystatin when tested in combination with triamcinolone acetonide. Triamcinolone acetonide was detected in the saliva of both patients after treatment. Addition of this saliva to the isolates of C. albicans obtained after treatment was found to confer nystatin resistance. Both patients were treated with miconazole nitrate and a mycological and clinical cure was obtained in one of the cases.
本文描述了两例口腔念珠菌病患者，在使用制霉菌素联合曲安奈德治疗时无效。治疗后从患者分离出的白色念珠菌菌株，在与曲安奈德联合测试时，显示出对制霉菌素的高体外耐药性。治疗后在两名患者的唾液中均检测到曲安奈德。将这种唾液添加到治疗后获得的白色念珠菌分离株中，发现会产生制霉菌素耐药性。两名患者均接受硝酸咪康唑治疗，其中一例实现了真菌学和临床治愈。
