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[底物结合后酵母磷酸甘油酸激酶分子的大规模结构变化]

[Large-scale structural changes of yeast phosphoglycerate kinase molecule upon substrate binding].

作者信息

Timchenko A A, Tsiuriupa S N

出版信息

Biofizika. 1982 Nov-Dec;27(6):1017-21.

PMID:6760903
Abstract

Changes of dimensions and form of the yeast phosphoglyceratekinase molecule upon ATP and 3-phosphoglycerate binding have been investigated by diffuse X-ray scattering. It has been shown that simultaneous sorption of both substrates is accompanied by an essential decrease both of the radius of gyration and the extent of asymmetry of the phosphoglyceratekinase molecule.

摘要

通过漫散射X射线研究了酵母磷酸甘油酸激酶分子在结合ATP和3-磷酸甘油酸后尺寸和形状的变化。结果表明,两种底物的同时吸附伴随着磷酸甘油酸激酶分子的回转半径和不对称程度的显著降低。

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