Senft H H, Korte W
Chemotherapy. 1982;28 Suppl 1:3-13. doi: 10.1159/000238145.
The clinical picture of candidal vaginitis was described for the first time in 1792. The connection with yeasts was already discovered in the 19th century. Not until the last 35 years, however, have the epidemiologic aspects of genital mycoses and the diagnostic and therapeutic principles been systematically developed. The rise in the incidence of the disease is due to several factors: the administration of corticosteroids, cystostatic agents, and oral contraceptives as well as socioeconomic circumstances. Two serious complications of vaginal yeast infection in pregnant women should be noted: the amniotic infection syndrome and neonatal contamination at the time of delivery. Vulvovaginitis is one of the most common genital diseases in childhood and adolescence. Mycoses can be diagnosed in daily gynecological practice by simple, reliable methods, but only culture on prepared media or by incubation of standardized plates can be depended upon to establish or rule out a mycosis. Effective antimycotics with a broad spectrum of activity have been developed in the last 15 years. We have been primarily concerned with clotrimazole because of our own investigations and impartial comparisons with other fungicidal drugs. Studies of patient compliance have shown that the diseased women accept short-term therapy most readily. However, appropriate control examinations are needed to document the results of treatment.
1792年首次描述了念珠菌性阴道炎的临床表现。19世纪已发现其与酵母菌的关联。然而，直到最近35年，生殖器霉菌病的流行病学方面以及诊断和治疗原则才得到系统发展。该疾病发病率上升归因于多种因素：使用皮质类固醇、抑制细胞生长剂和口服避孕药以及社会经济状况。应注意孕妇阴道酵母菌感染的两种严重并发症：羊膜感染综合征和分娩时新生儿感染。外阴阴道炎是儿童和青少年中最常见的生殖器疾病之一。在日常妇科实践中，霉菌病可用简单、可靠的方法诊断，但只有在特制培养基上培养或通过标准化平板孵育才能确定或排除霉菌病。过去15年已研发出具有广泛活性的有效抗真菌药。基于我们自己的研究以及与其他杀真菌药物的公正比较，我们主要关注克霉唑。对患者依从性的研究表明，患病女性最容易接受短期治疗。然而，需要进行适当的对照检查以记录治疗结果。
