Vialettes B, Beaume D, Vague P
Diabete Metab. 1982 Dec;8(4):349-55.
Many observations suggest that auto-immune process are activated during the beta-cell destruction in insulin-dependent diabetes (IDD): they include association with organ specific auto-immune disease, frequency of circulating anti-organ antibodies, circulating anti-islet cell antibodies, insulitis-like lesions in the pancreas and in vitro lymphocytic reaction against pancreatic antigens. However, it is still uncertain if these reactions are actually involved in the beta cell destruction. Cytotoxicity experiments on beta cells in culture and animal models support this hypothesis. Nosologic classification which categorizes an autoimmune type of IDD, a viral type of IDD and a large proportion termed idiopathic IDD may be a useful device to further our understanding of the pathogenic pathways but may be open to criticism of undue simplification as in this presumably multifactorial disease, the differences between affected individuals may be quantitative and not qualitative.
许多观察结果表明，在胰岛素依赖型糖尿病（IDD）的β细胞破坏过程中，自身免疫过程被激活：这些观察结果包括与器官特异性自身免疫疾病的关联、循环抗器官抗体的频率、循环抗胰岛细胞抗体、胰腺中的胰岛炎样病变以及体外针对胰腺抗原的淋巴细胞反应。然而，这些反应是否实际参与了β细胞的破坏仍不确定。对培养的β细胞进行的细胞毒性实验和动物模型支持了这一假设。将IDD分类为自身免疫型、病毒型以及很大一部分称为特发性IDD的疾病分类法，可能是一种有助于我们进一步理解致病途径的有用方法，但可能会受到过度简化的批评，因为在这种可能由多种因素引起的疾病中，受影响个体之间的差异可能是数量上的而非质量上的。
