Autio K, von Wright A, Pyysalo H
Mutat Res. 1982 Nov;106(1):27-31. doi: 10.1016/0027-5107(82)90188-9.
Ethylenethiourea is metabolized in mice by oxidation of the sulfur atom to form 2-imidazolin-2-yl sulfenate. Ethylenethiourea itself is a carcinogen, goitrogen, teratogen and a weak bacterial mutagen. The mutagenicities of ethylenethiourea, 2-imidazolin-2-yl sulfenate and their nitroso derivatives were compared in direct bacterial tests and in the host-mediated assay. In all the test systems applied, 2-imidazolin-2-yl sulfenate was less mutagenic than the parent compound.
乙烯硫脲在小鼠体内通过硫原子氧化代谢形成2-咪唑啉-2-基亚磺酸酯。乙烯硫脲本身是一种致癌物、致甲状腺肿物质、致畸剂和弱细菌诱变剂。在直接细菌试验和宿主介导试验中比较了乙烯硫脲、2-咪唑啉-2-基亚磺酸酯及其亚硝基衍生物的诱变性。在所有应用的测试系统中，2-咪唑啉-2-基亚磺酸酯的诱变性均低于母体化合物。
