Koss L G
Anal Quant Cytol. 1982 Dec;4(4):251-6.
A brief history of the development of analytical and quantitative cytology is presented. In particular, the origins of planimetry and of cytochemical studies on DNA quantitation are discussed: these two endeavors defined many of the parameters that are now being studied by computerized analytical systems. Special attention is given to the development of the Cytoanalyzer, the first automatic scanning device for diagnostic purposes. The problems with cell collection and specimen preparation that beset that early cytoanalytic system remain unsolved with the current high-resolution cell image analysis systems. The developments in flow cytometry, which had origins similar to those of high-resolution studies, are also discussed.
本文介绍了分析和定量细胞学发展的简史。特别讨论了平面测量法的起源以及DNA定量的细胞化学研究：这两项工作定义了许多目前由计算机分析系统研究的参数。文中特别关注了细胞分析仪的发展，它是第一台用于诊断目的的自动扫描设备。困扰早期细胞分析系统的细胞收集和标本制备问题，在当前的高分辨率细胞图像分析系统中仍然没有得到解决。文中还讨论了流式细胞术的发展，其起源与高分辨率研究的起源相似。
