de Mascarel I, Trojani M, Abadjian G, Durand M, Bonichon F, Coindre J M, Meuge-Moraw C
Bull Cancer. 1982;69(5):451-5.
Lymph nodes in breast cancer have been examined by two histological techniques in 324 patients who underwent axillary node dissection. A routine pathologic examination consisted in the examination of only one pathological section while in the other, the lymph nodes were macroscopically serially sectioned. With the latter, an increase of 18.8 per cent in the number of detected metastases was noted. However this increase can be considered of prognostic and therapeutic importance only in 8.6 per cent of cases: half corresponding to those cases in which more than the initial threshold number of three lymph nodes were found, the other half corresponding to those cases in which one lymph node was found while the initial examination was negative. In the latter case, the increase of lymph node involvement was mainly due to "clandestine" metastases, i.e. lymphatic embolisation of micrometastases.
对324例行腋窝淋巴结清扫术的患者，运用两种组织学技术检查其乳腺癌淋巴结。常规病理检查仅检查一个病理切片，而另一种方法是对淋巴结进行宏观连续切片。采用后一种方法时，检测到的转移灶数量增加了18.8%。然而，仅在8.6%的病例中，这种增加才具有预后和治疗意义：其中一半对应于发现的淋巴结数量超过初始阈值三个的病例，另一半对应于初次检查为阴性但发现一个淋巴结的病例。在后一种情况下，淋巴结受累增加主要归因于“隐匿性”转移，即微转移的淋巴栓塞。
