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[预防性抗菌药物在阑尾切除术后感染性并发症中的合理应用。一项对照临床试验]

[Logical use of prophylactic antibacterial agents in infectious post-appendectomy complications. A controlled clinical trial].

作者信息

Abdel-Lah B A, Fernández Alvarez D, Lozano Sánchez F, Alvarez Aparicio E, Gómez Alonso A, Salazar A-Villalobos V

出版信息

An Esp Pediatr. 1982 Nov;17(5):383-9.

PMID:6762829
Abstract

A prospective clinical trial is carried out in 88 patients undergoing surgery for removal of the appendix. Authors show the efficacy of the association of pre and postoperative gentamycin plus clindamycin or lincomycin in prevention of postoperative infections, which, in the cases with non-ruptured appendix was 0%, and in gangrenous or perforated cases was 8.6%, with a global infection rate of 6% in this prophylactic subgroup I. However, when the same antibiotics are administered only postoperatively (subgroup II), global infection rate is of 34.2% similar to data in the literature in which no antibiotics were given. There have been no complications derived from this antibiotic prophylaxis.

摘要

对88例接受阑尾切除手术的患者进行了一项前瞻性临床试验。作者表明,术前和术后联合使用庆大霉素加克林霉素或林可霉素在预防术后感染方面具有疗效,在阑尾未破裂的病例中,感染率为0%,在坏疽或穿孔病例中为8.6%,在该预防性亚组I中总体感染率为6%。然而,当相同的抗生素仅在术后使用时(亚组II),总体感染率为34.2%,与未使用抗生素的文献数据相似。这种抗生素预防措施未引发任何并发症。

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