Friedrich F, Kemeter P, Salzer H, Kratochwil A, Knapp-Groll E
Wien Klin Wochenschr. 1978 Aug 11;90(15):534-45.
Hormone profiles in early pregnancy were established in 67 women and correlated to simultaneously performed ultrasonic examinations. Normal values for human chorionic gonadotropin (HCG), human chorionic somatotropin (HCS), oestradiol (E2) and progesterone (P) were established from the data obtained in 30 early pregnancies which culminated in the birth of a living child. Lowered HCG values were found in 17 out of 23 pregnancies which ended in miscarriage. In these cases ultrasonic examination failed to detect any heart action. Lowered HCS values after the 9th week of pregnancy are also certain proof of missed abortion. P and E2 values are shown to be a parameter reflecting activity of the corpus luteum graviditatis. In clomiphene- and gonadotropin-induced pregnancies higher values were found than in pregnancies managed by substitution treatment with twice weekly 10 mg oestradiolvalerianate + 500mg 17alpha-hydroxyprogesteronecapronate. Lowered P and E2 values with HCG values in the normal range indicate imminent insufficiency of the corpus luteum graviditatis. Pros and cons of hormonal therapy in early pregnancy are discussed.
对67名女性的孕早期激素水平进行了测定，并与同期进行的超声检查结果进行了关联分析。根据30例最终分娩活婴的早期妊娠数据，确定了人绒毛膜促性腺激素（HCG）、人绒毛膜生长激素（HCS）、雌二醇（E2）和孕酮（P）的正常值。在23例以流产告终的妊娠中，有17例发现HCG值降低。在这些病例中，超声检查未能检测到任何心跳。妊娠第9周后HCS值降低也是稽留流产的明确证据。P和E2值被证明是反映妊娠黄体活性的一个参数。与每周两次用10mg戊酸雌二醇+500mg 17α-羟孕酮己酸酯替代治疗的妊娠相比，克罗米芬和促性腺激素诱导的妊娠中这些值更高。P和E2值降低而HCG值在正常范围内表明妊娠黄体即将功能不全。本文讨论了孕早期激素治疗的利弊。
