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[吉兰-巴雷综合征病史]

[History of Guillain-Barré syndrome].

作者信息

Schott B

出版信息

Rev Neurol (Paris). 1982;138(12):931-8.

PMID:6763295
Abstract

1916: birth in Paris of a modest syndrome presented to a weekly meeting of the Société Médicale by Georges Guillain, Jean-Alexandre Barré and André Strohl. 1981: glorification of the syndrome as a world event in Santa Inez Valley at the International Conference held under the auspices of the Kroc Foundation. This is indeed a long way from a few clinicians and internists to the representatives of all branches of the Neurological Sciences for "la radiculo-névrite avec dissociation albumino-cytologique à évolution spontanément régressive "studied in two soldiers of the Vth French Army. Every neurologist from clinician to researcher currently knows this model of inflammatory and demyelinating diseases of the peripheral nervous system and the pros and cons of cellular vs humeral immunity which are presumed to be its pathophysiological process. What is less known is "la petite histoire" i.e. that of men and events which surrounded its birth and growth to being an entity. Why did André Strohl disappear? Who were L. Duménil and O. Landry? Should we say Guillain-Barré?, Landry-Guillain-Barré?, Duménil-Landry-Guillain-Barré? Unexpected or poorly known facts are not lacking in this story the last of which being that most references to that most French syndrome are to be found in English and American books.

摘要

1916年:一种不太知名的综合征在巴黎诞生,乔治·吉兰(Georges Guillain)、让 - 亚历山大·巴雷(Jean-Alexandre Barré)和安德烈·斯特罗尔(André Strohl)在法国医学协会的一次周会上介绍了该综合征。1981年:在克罗克基金会主持下于圣伊内斯山谷举行的国际会议上,该综合征被视为一项世界性事件而备受赞誉。从最初的几位临床医生和内科医生,发展到神经科学各分支的代表,研究对象是法国第五集团军两名士兵所患的“伴有蛋白细胞分离且自发缓解的神经根神经炎”,这一路走来确实经历了漫长的历程。如今,从临床医生到研究人员,每位神经科医生都知晓这种周围神经系统炎性脱髓鞘疾病的模型,以及被认为是其病理生理过程的细胞免疫与体液免疫的利弊。然而,鲜为人知的是“小故事 ”,即围绕其诞生、发展直至成为一个独立病种的人和事。安德烈·斯特罗尔为何销声匿迹?L. 迪梅尼尔(L. Duménil)和O. 兰德里(O. Landry)是谁?我们应该称其为吉兰 - 巴雷综合征(Guillain-Barré syndrome)吗?兰德里 - 吉兰 - 巴雷综合征(Landry-Guillain-Barré syndrome)?迪梅尼尔 - 兰德里 - 吉兰 - 巴雷综合征(Duménil-Landry-Guillain-Barré syndrome)?这个故事不乏意外或鲜为人知的事实,其中最后一点是,关于这种极具法国特色的综合征的大多数参考文献都能在英文和美国书籍中找到。

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