钠、脱氧皮质酮及高血压持续时间对大鼠升压反应的影响。

Effect of sodium, deoxycorticosterone and duration of hypertension on pressor responses in rats.

作者信息

Bing R F, Russell G I, Swales J D, Thurston H

出版信息

J Physiol. 1982 Dec;333:383-91. doi: 10.1113/jphysiol.1982.sp014459.

DOI:10.1113/jphysiol.1982.sp014459

PMID:6763628

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1197254/

Abstract

Enhanced pressor responsiveness to angiotensin II and noradrenaline has been demonstrated in the hypertension that follows deoxycorticosterone (DOC) and salt administration in the rat. The present studies were carried out to assess the importance of factors common to both pressor agents and those specific to individual agents such as receptor availability.2. Accordingly pressor reponses to angiotensin II and noradrenaline have been studied in normotensive salt-loaded and sodium depleted rats with and without DOC, and in rats with DOC-salt hypertension of short and long duration. These responses have been related to the plasma renin levels in the animals studied.3. Pressor reponses to angiotensin II were increased, dose-response curve (d.r.c.) shifted to the left, in salt-loaded rats and the administration of DOC produced a further increase. DOC-salt hypertension of short duration was associated with an even greater responsiveness. Sodium depletion, however, reduced responsiveness (d.r.c. shifted to the right) and concurrent DOC administration did not alter this. Angiotensin II responses were closely correlated with plasma renin concentration over a wide range of values (p.r.c, r = -0.77, P < 0.001). The differences between the groups could be explained therefore by the number of unoccupied angiotensin II receptors available.4. On the other hand only sodium loaded rats that were also receiving DOC showed any change in noradrenaline responsiveness, when the dose-response curve was shifted to the left. Noradrenaline responses showed no linear relationship to plasma renin concentration.5. The presence of hypertension did not significantly alter noradrenaline responses and the increase observed in angiotensin II responsiveness could be explained by the greater suppression of plasma renin in this group. Duration of hypertension had no effect on responsiveness to either agent.6. These results point to important differences in the pressor responsiveness to angiotensin II and noradrenaline with variation of salt intake and DOC administration.

摘要

给大鼠注射脱氧皮质酮（DOC）并给予高盐饮食后引发的高血压中，已证实对血管紧张素II和去甲肾上腺素的升压反应增强。开展本研究旨在评估这两种升压药共有的因素以及诸如受体可用性等各药特有的因素的重要性。
因此，研究了正常血压、高盐饮食和低盐饮食的大鼠在给予和未给予DOC的情况下对血管紧张素II和去甲肾上腺素的升压反应，以及短期和长期DOC - 盐性高血压大鼠的反应。这些反应与所研究动物的血浆肾素水平相关。
在高盐饮食的大鼠中，对血管紧张素II的升压反应增强，剂量 - 反应曲线（d.r.c.）左移，给予DOC后反应进一步增强。短期DOC - 盐性高血压与更强的反应性相关。然而，低盐饮食会降低反应性（d.r.c.右移），同时给予DOC并不会改变这一情况。在很宽的数值范围内，血管紧张素II反应与血浆肾素浓度密切相关（p.r.c，r = -0.77，P < 0.001）。因此，各组之间的差异可以用可用的未占据血管紧张素II受体数量来解释。
另一方面，只有同时接受DOC的高盐饮食大鼠的去甲肾上腺素反应性有变化，此时剂量 - 反应曲线左移。去甲肾上腺素反应与血浆肾素浓度无线性关系。
高血压的存在并未显著改变去甲肾上腺素反应，而血管紧张素II反应性的增加可以用该组血浆肾素受到更大抑制来解释。高血压持续时间对两种药物的反应性均无影响。
这些结果表明，随着盐摄入量和DOC给药的变化，对血管紧张素II和去甲肾上腺素的升压反应存在重要差异。