Belonje P C, Jaros G G, van den Berg A
J S Afr Vet Assoc. 1982 Dec;53(4):229-31.
An intravenous compound 5% calcium solution was subjected to three trials in S.A. Mutton Merino X Merino ewes to establish its safety and also to resultant levels of blood total and particularly ionized calcium. In the first trial, 10 animals each received 20 ml of the compound but the administration time progressively decreased from 90 seconds in the first to only 15 seconds in the last ewe. Plasma total calcium levels more than doubled in all the animals and, except for transient disorientation in the last ewe, nothing untoward was noted. In the second trial 4 ewes again received 20 ml of the compound while in the third trial 5 ewes received the compound at the rate of 0,5 ml/kg. In both trials the administration time was about 30 seconds. Plasma total and ionized calcium levels more than doubled initially and, while there was a steady and parallel decline in both, they were still more than 60% higher than pre-injection levels after as long as 2 hours.
对南澳大利亚美利奴绵羊与美利奴母羊杂交的母羊进行了三项试验，以确定静脉注射5%复方钙溶液的安全性以及由此产生的血液总钙水平，特别是离子钙水平。在第一项试验中，10只动物每只接受20毫升该复方溶液，但给药时间从第一只母羊的90秒逐渐减少到最后一只母羊的仅15秒。所有动物的血浆总钙水平增加了一倍多，除了最后一只母羊出现短暂定向障碍外，未观察到任何不良情况。在第二项试验中，4只母羊再次接受20毫升该复方溶液，而在第三项试验中，5只母羊以0.5毫升/千克的速率接受该复方溶液。在两项试验中，给药时间均约为30秒。血浆总钙和离子钙水平最初增加了一倍多，虽然两者均呈稳定且平行下降，但长达2小时后仍比注射前水平高出60%以上。
