Romics L, Karádi I, Rozenberczki M, Kammerer L
Acta Med Acad Sci Hung. 1982;39(3-4):117-23.
In diabetic patients with poor metabolic control (Group I) and with repeated hypoglycaemic crises (Group II) the serum concentration of cholesterol, triglyceride, of LDL, VLDL and HDL-cholesterol, as well of VLDL and LDL + HDL-triglyceride were measured before and after metabolic control and before and after control of the hypoglycaemic crises. Parallel with the control of diabetic metabolism in Group I, achieved in 15 +/- 6 days, a significant increase in HDL-cholesterol concentration was demonstrable, together with a decrease in the mean value of blood glucose and of daily urinary glucose excretion. In the diabetic patients of Group I, the LDL-cholesterol, serum triglyceride and VLDL-triglyceride levels were significantly higher, the HDL cholesterol levels significantly lower before as well as after metabolic correction, than in the control group. In Group II the serum lipid and lipoprotein lipid concentrations remained unaffected by the control of the hypoglycaemic crises. The results indicate that lipid metabolism in diabetes may considerably be affected by insulin deficiency, but it will respond to an intensified insulin effect. An increase in the concentration of the antiatherogenic HDL-cholesterol is an essential factor of the improvement.
在代谢控制不佳的糖尿病患者（第一组）和反复发生低血糖危象的糖尿病患者（第二组）中，分别在代谢控制前后以及低血糖危象控制前后，测定了胆固醇、甘油三酯、低密度脂蛋白、极低密度脂蛋白和高密度脂蛋白胆固醇的血清浓度，以及极低密度脂蛋白和低密度脂蛋白 + 高密度脂蛋白甘油三酯的血清浓度。在第一组中，经过15±6天实现糖尿病代谢控制后，高密度脂蛋白胆固醇浓度显著升高，同时血糖平均值和每日尿糖排泄量降低。在第一组糖尿病患者中，无论代谢纠正前后，低密度脂蛋白胆固醇、血清甘油三酯和极低密度脂蛋白甘油三酯水平均显著高于对照组，而高密度脂蛋白胆固醇水平则显著低于对照组。在第二组中，低血糖危象的控制对血清脂质和脂蛋白脂质浓度没有影响。结果表明，糖尿病中的脂质代谢可能会受到胰岛素缺乏的显著影响，但会对强化的胰岛素作用产生反应。抗动脉粥样硬化的高密度脂蛋白胆固醇浓度升高是病情改善的一个重要因素。
