Mohan R, Mohan V, Susheela L, Ramachandran A, Viswanathan M
Acta Diabetol Lat. 1984 Jan-Mar;21(1):85-9.
Serum cholesterol and its various lipoprotein fractions and triglycerides were measured in 50 non-insulin-dependent diabetic patients, 25 without retinopathy (group A) and 25 with diabetic maculopathy (group B) initially before control of diabetes, and again, after achieving good metabolic control. The lipid parameters were also estimated in 25 healthy non-diabetic subjects. The groups were well matched for sex, age, duration of diabetes and body weight. Mean serum total cholesterol and LDL cholesterol levels were significantly higher in group B when compared to group A, before and after achieving good metabolic control of diabetes (p less than 0.001). Mean total/HDL cholesterol and mean LDL/HDL cholesterol ratios were also significantly increased in group B as compared to group A (p less than 0.01) both before and after good diabetic control in these patients. Mean serum HDL and VLDL cholesterol and triglyceride concentrations were similar in groups A and B. The mean serum lipid concentrations in the diabetic patients without retinopathy (group A) were comparable to those of non-diabetic subjects.
对50例非胰岛素依赖型糖尿病患者进行了血清胆固醇及其各种脂蛋白组分和甘油三酯的检测，其中25例无视网膜病变（A组），25例有糖尿病性黄斑病变（B组），最初在糖尿病控制前进行检测，在实现良好的代谢控制后再次检测。还对25名健康非糖尿病受试者的脂质参数进行了评估。这些组在性别、年龄、糖尿病病程和体重方面匹配良好。在糖尿病实现良好代谢控制前后，B组的平均血清总胆固醇和低密度脂蛋白胆固醇水平与A组相比均显著更高（p<0.001）。在这些患者糖尿病良好控制前后，B组的平均总胆固醇/高密度脂蛋白胆固醇和平均低密度脂蛋白胆固醇/高密度脂蛋白胆固醇比值也均显著高于A组（p<0.01）。A组和B组的平均血清高密度脂蛋白、极低密度脂蛋白胆固醇和甘油三酯浓度相似。无视网膜病变的糖尿病患者（A组）的平均血清脂质浓度与非糖尿病受试者相当。
