Scheld W M
J Infect. 1981 Mar;3(1 Suppl):5-19. doi: 10.1016/s0163-4453(81)80003-5.
This review summarises briefly several areas of importance in the pathogenesis of bacterial meningitis. These subjects include: (1) factors that predispose to the development of disease and relevant host defense mechanisms; (2) microbial virulence factors; (3) the route(s) of entry for bacteria into the cerebrospinal fluid (CSF); (4) the role of pathological changes in the central nervous system; (5) particulate clearance mechanisms operative in the CSF system; and (6) the physiological alteration in normal intracranial homeostatic processes.
本综述简要总结了细菌性脑膜炎发病机制中几个重要的领域。这些主题包括：（1）易患疾病的因素及相关宿主防御机制；（2）微生物毒力因子；（3）细菌进入脑脊液（CSF）的途径；（4）中枢神经系统病理变化的作用；（5）CSF系统中起作用的微粒清除机制；以及（6）正常颅内稳态过程中的生理改变。
