实验性麻风病中的肥大细胞与麻风分枝杆菌
Mast cell and Mycobacterium leprae in experimental leprosy.
作者信息
Kumar R, Vaidya M C
出版信息
Hansenol Int. 1982 Jun;7(1):1-7.
The association of mast cells and lepra bacilli was studied in the foot pad skin of immunosuppressed mice inoculated with 10(5) lepra bacilli. The mice were killed at intervals varying from 2 1/2-14 months postinoculation. M. leprae are found in large numbers in nerves, blood vessels, muscle fibres, hair follicles, sweat and sebaceous glands. Mastocytosis and extensive degranulation are seen at similar sites. Since these are the structures most affected in leprosy where the lepra bacilli and degranulating mast cells accumulate, there appears a close relationship between the two. This could be due to the composite role of mast cells in host tissue response and mastocytosis and degranulation may be related to this.
在接种了10⁵条麻风杆菌的免疫抑制小鼠的足垫皮肤中，研究了肥大细胞与麻风杆菌的关联。在接种后2个半月至14个月的不同时间间隔处死小鼠。在神经、血管、肌纤维、毛囊、汗腺和皮脂腺中发现大量麻风分枝杆菌。在类似部位可见肥大细胞增多症和广泛的脱颗粒现象。由于这些是麻风病中受影响最严重的结构，麻风杆菌和脱颗粒的肥大细胞在此积聚，二者之间似乎存在密切关系。这可能是由于肥大细胞在宿主组织反应中的综合作用，肥大细胞增多症和脱颗粒可能与此有关。
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