Millán Núñez-Cortés J
Rev Esp Oncol. 1981;28(4):591-641 contd.
The author makes a review of several biological and clinical aspects of alpha-1-antitrypsin and describes some personal experiments in animals. The values of serum alpha-1-antitripsin are 384.50 +/- 96.25 mg/100 ml in normal individuals, 479.19 +/- 163.76 mg/100 ml in several non-tumoral diseases, and 722.55 +/- 360.99 mg/100 ml in cancer patients. The changes in serum alpha-1-antitrypsin concentration may be useful to distinguish localized tumors (587.45 +/- 251.12 mg/100 ml), invasion of regional lymph nodes (650.9 +/- 280.51 mg/100 ml), and disseminated cancers (848.51 +/- 396.14 mg/100 ml), and to follow tumor evolution. Experiments with the Ehrlich ascites cancer of the mouse carried out by the author show that a correlation exists between tumor mass and serum antitryptic activity.
作者对α-1-抗胰蛋白酶的几个生物学和临床方面进行了综述，并描述了一些在动物身上进行的个人实验。正常个体血清α-1-抗胰蛋白酶的值为384.50±96.25mg/100ml，几种非肿瘤疾病患者为479.19±163.76mg/100ml，癌症患者为722.55±360.99mg/100ml。血清α-1-抗胰蛋白酶浓度的变化可能有助于区分局限性肿瘤（587.45±251.12mg/100ml）、区域淋巴结转移（650.9±280.51mg/100ml）和播散性癌症（848.51±396.14mg/100ml），并跟踪肿瘤进展。作者进行的小鼠艾氏腹水癌实验表明，肿瘤大小与血清抗胰蛋白酶活性之间存在相关性。
